I had a weird reaction at the end of 50/50 where my eyes started watering. It happened a few times throughout the film too. I’m not admitting it was tears, but I’m waiting on official word from the doctor before I make any claims. Thankfully, Jonathan Levine‘s cancer comedy adds just as much laughs as it does drama. We now have a second trailer that sells just about only that.

Produced by Evan Goldberg and Seth Rogen, there is even a title here that credits their hit Superbad. While it is quite funny, I encourage you to check out the first trailer beforehand if you haven’t, since there is much more meat to this story that this hints at. See the new trailer below via Yahoo for the film starring Joseph Gordon-Levitt, Seth Rogen, Anna Kendrick, Bryce Dallas Howard and Anjelica Huston.

Synopsis:

Inspired by personal experiences, 50/50 is an original story about friendship, love, survival and finding humor in unlikely places. Joseph Gordon-Levitt and Seth Rogen star as best friends whose lives are changed by a cancer diagnosis. Rogen also serves as producer, along with Evan Goldberg and Ben Karlin. Jonathan Levine directs from a script by Will Reiser. “We worked with Will on Da Ali G show, and it was shortly after that we learned he was sick.” Rogen recalls. “As shocking, sad, confusing and generally screwed up as it was; we couldn’t ignore that because we were so ill-equipped to deal with the situation, funny things kept happening. Will got better, and when he did, we thought the best way to pull something good out of the situation was to get him to write a screenplay. Ideally we wanted to make a film that would be as funny, sad, and hopefully as honest as the experience we went through. As soon as the script was completed, it quickly became a passion project for all of us. It helped us come to terms with Will’s struggle as well as our own experiences.” 50/50 is the story of a guy’s transformative and, yes, sometimes funny journey to health. 50/50 draws its emotional core from Will Reiser’s own experience with cancer and reminds us that friendship and love, no matter what bizarre turns they take, are the greatest healers.

50/50 hits theaters September 30th, 2011 and will play at Toronto International Film Festival.

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